Overview:

The hunger and horomones study is all about how the body responds to high glucose levels in individuals with Type 1 Diabetes.

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Study Details:

We will recruit 50 individuals with Type 1 Diabetes to take part in the study. Based on certain qualifications, each participant will be separated into an experimental or control group condition. Participants included in the experimental group will be individuals who report problems with over-eating, or binge eating, and under dosing of insulin.

 

The control group will be asked to take part in ONE meal replacement test.

 

The experimental group will be asked to take part in TWO meal replacement tests scheduled approximately 1 week apart.

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All participants will be asked to arrive at the clinic after an overnight fast.

 

All participants will complete a diagnostic interview along with assessment measures on the computer.

 

All participants will conduct a standard finger stick blood glucose check to ensure adequate glucose control prior to the study.

 

All participants will have blood drawn to assess plasma concentrations of ghrelin (a hormone that impacts hunger), insulin and glucose.

 

All CONTROL GROUP participants will then be asked to administer their usual dose of short-acting insulin (brought from home) based on their blood sugar and insulin to carb ratio and consume 8 oz. of Ensure. All participants will be asked to finish drinking the Ensure within 5 minutes.

 

All EXPERIMENTAL GROUP participants will be randomized to either a dosing, or non-dosing condition on their first week. If randomized to the non-dosing condition, participants will be asked to consume 8 oz. of Ensure without taking their short-acting insulin. If randomized to the dosing condition, participants will be asked to administer their usual dose of short acting insulin. Based on randomization this first week, all experimental group participants will return the following week and repeat the meal replacement as part of the opposite condition from their first week.

 

After the initial baseline blood draws, draws will occur at 4 additional time points (after 30, 60, 90, and 120 minutes). Participants will also be asked about your appetite/hunger at these time points.